Alpha-lipoic acid inhibits oxidative DNA damage of some organs induced by 4-tert-octylphenol exposure in rats

Endocrine disputer chemicals (EDCs) such as 4-tert-octylphenol (OP), are a class of exogenous pollutants that can interfere with normal physiological processes, resulting in number health issues. Therefore, the goal current study is to determine how well α -lipoic acid (LA) protects against DNA damage brought on by OP. Forty male albino rats were randomly assigned into four groups. Group I (control group) not received any material, group II (αLA-group) α-lipoic (40 mg/kg/ day), III (OP-group) (50 and IV(protective day) plus mg\ kg/ for period 30 days. The fragmentations detected tissues hypothalamus, pituitary gland testis using agarose gel electrophoresis bands visualized under UV light total concentration samples also measured spectrophotometrically. Rats administered OP showed significant (p < 0.05) rising levels non-significantly >0.05) increase hypothalamus tissue. On other hand, αLA treatment improvement levels.